Pathophysiology of RLS

Restless Legs Syndrome (RLS) is a neurological condition affecting approximately 10% of adults in the United States. For about one-third of patients with RLS, the symptoms are severe enough to require medical therapy. RLS is twice as common in women, and the risk for developing the condition increases with age.1-4

RLS is commonly known as primary RLS, which means the disease is chronic and often hereditary. RLS can also occur secondary to other conditions such as iron deficiency, renal failure, or pregnancy.4

The underlying cause of primary RLS remains unknown. Researchers have discovered that abnormalities in brain dopamine and low iron concentration in the brain are likely contributing factors. The relationship between these factors is not yet fully understood.4,5

For many patients, RLS can be debilitating—disrupting sleep, influencing mood, and negatively impacting quality of life. Appropriate diagnosis and management are critical to patient care.6

rls affects approximately 10% of adults in the US
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